Faculty & School/Dept.
Faculty of Health - School of Kinesiology & Health Science
Ph.D Physiology - 1986
State University of New York
B.A. Physical & Health - 1979
M.Sc Physical Education - 1981
B.P.H.Education - 1979
Papers in refereed journals
Oliveira, A.N., B. Yanagawa, S. Verma and D.A. Hood. Blunted stress response with age in right atrial tissue following ischemia-reperfusion. J. Card Surg. (submitted Feb 2021)
Cheema, N., J.M. Cameron and D.A. Hood. Mitochondrial dysfunction in fibroblasts with mtDNA defects is attenuated with rapamycin treatment. Am. J. Physiol. Cell Physiol. (in revision, Feb 2021).
Oliveira, A.N., B. Richards, M. Slavin and D.A. Hood. Exercise is mitochondrial medicine for muscle. Exerc. Sport Sci. Reviews (in press) 2021.
Memme, J.M. and D.A. Hood. Molecular basis for the therapeutic effects of exercise on mitochondrial defects. Frontiers Physiol. (in press), 2021.
Islam, H., D.A Hood and B.J. Gurd. Looking beyond PGC-1α: emerging regulators of exercise-induced skeletal muscle mitochondrial biogenesis and their activation by dietary compounds. Appl Physiol Nutr Metab. 45:11-23, 2020.
Zhang Y, A.N. Oliveira, D.A. Hood. The intersection of exercise and aging on mitochondrial protein quality control. Exp Gerontol.131:110824. doi:10.1016/j.exger.2019.110824, 2020.
Erlich, A. T. and D. A. Hood. Mitophagy regulation in skeletal muscle: Effect of endurance exercise and age. Journal of Science in Sport and Exercise. Accepted September 25, 2019
Oliveira, A. N. and D. A. Hood. Exercise is mitochondrial medicine for muscle. Sports Medicine and Health Science. 1:000-000, 2019
Memme, J. M., A. T Erlich, G. Phukan, and D. A. Hood. Exercise and mitochondrial health. J. Physiol. (Lond.) in press, 2019
M. Triolo, and D. A. Hood Mitochondrial breakdown in skeletal muscle and the emerging role of lysosomes. Arch. Biochem. Biophys. 661:66-73, 2019.
Kim, Y., M. Triolo, A. T Erlich, and D. A. Hood. Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations. Pfluger’s Arch. 471:431-440, 2019.
Hood, D.A., J.M. Memme, A.N. Oliveira and M. Triolo. Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Ann. Rev. Physiol. 81:19-41, 2019.
Beyfuss, K., A. T Erlich, M. Triolo and D. A. Hood. The Role of p53 in Determining Mitochondrial Adaptations to Endurance Training in Skeletal Muscle. Sci. Reports. 8:14710, 2018.
Oliveira, A.N., and D.A. Hood. Effect of Tim23 Knockdown in vivo on Mitochondrial Protein Import and Retrograde Signaling to the UPRmt in Muscle. Am J Physiol Cell Physiol. https://doi.org/10.1152/ajpcell.00275.2017,2018
Chen, C.C.W., A. T. Erlich, M. J. Crilly and D. A. Hood. Parkin is required for exercise-induced mitophagy in muscle: impact of aging. Am. J. Physiol. (Endocrin. Metab.) 315:E404-E415, 2018.
Carter, H.N., Y. Kim, A. T. Erlich, D. Zarrin-Khat and D. A. Hood. Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. J. Physiol. (Lond.) 596:3567-3584, 2018.
Chen C.C.W., A.T. Erlich and D.A. Hood. Role of Parkin and endurance training on mitochondrial turnover in skeletal muscle. Skelet. Muscle 8:10, 2018.
Carter, H.N., M. Pauly, L.D. Tryon and D. A. Hood. Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle. J. Appl. Physiol. 124:1605-1615, 2018.
Parousis, A., H. N. Carter, C. Tran, A. T. Erlich, Z. S. Mesbah-Moosavi, M. Pauly and D.A. Hood. Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells. Autophagy, 4:1-12, 2018.
Kim, Y., J. M. Memme and D.A. Hood. Application of chronic stimulation to study contractile activity-induced rat skeletal muscle phenotypic adaptations. J. Vis. Exp., e56827, 2018.
Beyfuss, K and D.A. Hood. A systematic review of p53 regulation of oxidative stress in skeletal muscle. Redox Report: https://doi.org/10.1080/13510002.2017.1416773, 2018.
Erlich A.T., D.M. Brownlee, K. Beyfuss and D.A. Hood. Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner. Am J Physiol Cell Physiol. 314: C62-C72, 2018. An image from this paper was chosen as the "Image of the week" on AJP-Cell Physiology Social Media (Oct 20, 2017).
Kim, Y, M. Triolo and D.A. Hood. Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle. Oxid Med Cell Longev. 2017:3165396, 2017.
Kim, Y and D.A.Hood. Regulation of the autophagy system during chronic contractile activity-induced muscle adaptations.Physiol Rep. 5(14):e13307, 2017.
Mesbah Moosavi Z.S. and D.A. Hood. The unfolded protein response in relation to mitochondrial biogenesis in skeletal muscle cells. Am. J. Physiol. Cell Physiol. 312:C583-C594, 2017. An image from this paper was chosen as the "Image of the week" on AJP-Cell Physiology Social Media.
Hornberger T.A., H.N. Carter, D.A. Hood, V.C. Figueiredo, E.E. Dupont-Versteegden, C.A. Peterson, J.J. McCarthy, D.M. Camera, J.A. Hawley, T. Chaillou, A.J. Cheng, G.A. Nader, R.C. Wust, R.H. Houtkooper. Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough. J. Appl. Physiol. 121:597-600, 2016.
Crilly, M.J., L.D. Tryon, A.T. Erlich and D.A. Hood. The role of Nrf2 in skeletal muscle contractile and mitochondrial function. J. Appl. Physiol. 121(3):730-40, 2016.
Hood, D.A., L.D. Tryon, H.N. Carter, Y. Kim and C.C.W. Chen. Unraveling the mechanisms regulating muscle mitochondrial biogenesis. Biochem. J. 473(15):2295-314, 2016.
Erlich, A.T., L.D. Tryon, M.J. Crilly, J. M. Memme, Z. S. Mesbah Moosavi, A.N. Oliveira, K. Beyfuss and D.A. Hood. Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis. Integr. Med. Res. 5(3):187-197, 2016.
Memme, J., A. Oliveira and D.A. Hood. The chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity. Am. J. Physiol. Cell Physiol. 310: C1024-C1036, 2016.
Vainshtein, A. and D.A. Hood. The regulation of autophagy during exercise in skeletal muscle. J. Appl. Physiol. 120: 664-673, 2016.
Hood, D.A., L.D. Tryon, A. Vainshtein, J. Memme, C. Chen, M. Pauly, M.J. Crilly and H. Carter, Exercise and the Regulation of Mitochondrial Turnover. In: Claude Bouchard (Ed.), Progress in Molecular Biology and Translational Science, 135: 99-127, 2015.
Tryon, L.D., M.J. Crilly and D.A. Hood. Effect of denervation on the regulation of mitochondrial transcription factor A expression in skeletal muscle. Am. J. Physiol. Cell Physiol. 309: C228-38, 2015.
Collu-Marchese, M., M. Shuen, M. Pauly, A. Saleem and D.A. Hood. The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation. Bioscience Reports 35: e00221, DOI: 10.1042/BSR20150073, 2015.
Carter, H.N., C.C.W. Chen and D.A. Hood. Mitochondria, Muscle Health and Exercise with Advancing Age. Physiology 30:208-223, 2015.
Vainshtein, A., E.M. Desjardins, A. Armani, M. Sandri, and D.A. Hood. PGC-1α modulates denervation-induced mitophagy in skeletal muscle. Skeletal Muscle 5:9, 2015.
Vainshtein, A., L.D. Tryon, M. Pauly, and D.A. Hood. The role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle. Am. J. Physiol. Cell Physiol. 308:C710-C719, 2015. (Paper-of-the-Year in this journal)
Muscle Health Research Centre, Faculty of Health, York University
York University Faculty of Health Established Career Research Award - 2009
Canadian Society for Exercise Physiology (CSEP) Honour Award - 2010
Distinguished Visiting Professor, Heart & Stroke / Richard Lewar Centre of Excellence in Cardiovascular Research - 2013
Peter A. Rechnitzer Lecturer, Centre for Physical Activity and Aging, Western University - 2013
York University Faculty of Health Established Career Teaching Award - 2013
Adam Barsky Lectureship on Mitochondrial Diseases, Hospital for Sick Children - 2014
Canadian Society for Exercise Physiology (CSEP) John R. Sutton Lecturer - 2015
Canadian Association for Graduate Studies (CAGS) Award for Outstanding Graduate Mentorship (Top 5 National Finalist) - 2019
Currently available to supervise graduate students: Yes
Currently taking on work-study students, Graduate Assistants or Volunteers: Yes
Available to supervise undergraduate thesis projects: Yes
Skeletal muscle biochemistry and molecular biology; mitochondrial turnover adaptations in muscle subject to chronic exercise, disuse or aging, including mechanisms of mitochondrial protein import and nuclear gene expression and mitophagy.
Mitochondria in Health and disease
Role: Principal Investigator
Amount funded: $1,400,000
Year Funded: 2017
Funded by: Canada Research Chairs
Mitochondrial and lysosomal biogenesis in aging muscle: effect of exercise
Role: Principal Investigator
Amount funded: $740,000
Year Funded: 2018
Funded by: Canadian Institutes of Health Research
Mitochondrial biogenesis in contracting muscle
Role: Principal Investigator
Amount funded: $325,000
Year Funded: 2016
Funded by: Natural Sciences and Engineering Research Council
Curriculum Vitae (C.V. file):
CV of David A Hood