Faculty & School/Dept.
Faculty of Health -
Porras DP, Abbaszadeh M, Bhattacharya D, D’Souza NC, Edjiu NR, Perry CGR, Scimè A, (2017). p107 determines a metabolic checkpoint required for adipocyte lineage fates. Stem Cells. Feb 23. doi:10.1002/stem.2576
Bhattacharya D, Ydfors M, Hughes MC, Norrbom J, Perry CGR and Scimè A, (2017). Decreased transcriptional co-repressor p107 is associated with exercise-induced mitochondrial biogenesis in human skeletal muscle. Physiological Reports. March 7, 2017: e13155
De Sousa M, Porras DP, Perry CG, Seale P, Scimè A, (2014). p107 is a crucial regulator for determining the adipocyte lineage fate choices of stem cell. Stem Cells. 2014 May;32(5):1323-36
Scimè A, (2012). The Heat is on: A New Avenue to Study Brown Fat Formation in Humans. Front Endocrinol (Lausanne). Jan 13;2:118. doi: 10.3389/fendo.2011.00118.
Scimè A, AZ. Caron and Grenier, G. Advances in myogenic cell transplantation and skeletal muscle tissue engineering. (2009). Frontiers in Bioscience. Jan 1;14:3012-23.
Le Grand F, Jones AE, Seale V., Scimè A, and Rudnicki MA. (2009). Wnt 7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell. June 5;4:535-47.
Seale P, Bjork B, Yang W, Kajimura S, Kuang S, Scimè A, Devarakonda S, Conroe H, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, and Spiegelman BM. (2008). PRDM16 controls a brown fat/skeletal muscle switch. Nature. Aug 21;454(7207):961-7.
Scimè A, and Rudnicki MA. Molecular-targeted therapy for duchenne muscular dystrophy: progress and potential. (2008). Molecular Diagnosis & Therapy. 12(2): 99-108.
Scimè A, and Rudnicki MA. Anabolic potential and regulation of muscle satellite cells. (2006). Current Opinion in Clinical Nutrition and Metabolic Care. May 9 (3): 214-19.
Scimè A, Grenier G, Huh MS, Gillespie MA, Bevilacqua L, Harper ME, and Rudnicki MA. (2005). Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metabolism. Nov;2(5):283-95.
Award of Excellence - 2006
University of Ottawa
Currently available to supervise graduate students: Yes
Currently taking on work-study students, Graduate Assistants or Volunteers: Yes
Available to supervise undergraduate thesis projects: Yes
The Scimè lab is focused on understanding the molecular, cellular and physiological aspects for how metabolism is involved in stem cell fate choices particularly in muscle and adipose tissue. Stem and progenitor cell fates have a profound impact on health and disease progression. Adipose and muscle tissue are inextricably linked to many metabolic pathways, and their dysregulation are associated with many complications and disease. No more so than in the ever-increasing prevalence of disorders such as type II diabetes, obesity, cancer and sarcopenia. A key component of muscle and adipose tissue function is provided by their stem cells that are necessary for tissue development, maintenance and disposition. For example, an important aspect in adipose and skeletal muscle stem cell function is their commitment to tissue subtypes, which play a crucial role in energy hemostasis. At the cellular level stem cell fate choices of quiescence, activation, differentiation and self-renewal are bio energetically balanced through proper regulation of metabolic pathways. At a whole body level fate decisions, are guided by their micro environment, which in turn is influenced by external physiological perturbations such as exercise, diet and disease. Ongoing studies are 1) to determine the role of cellular metabolism on stem cell fate choices in various tissue types 2) to assess the role of whole body stressors, such as exercise and diet on stem cell behavior and 3) to find the impact of altered metabolism on cancer stem function and micro environment.