Olasunkanmi A J Adegoke

Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science

Selected Publications

Interactions of the super complexes: When mTORC1 meets the proteasome. Adegoke OAJ, Beatty BE, Kimball SR, Wing SS. Int J Biochem Cell Biol. 2019 Dec;117:105638. Review.

Depletion of branched-chain aminotransferase 2 (BCAT2) enzyme impairs myoblast survival and myotube formation. Dhanani ZN, Mann G, Adegoke OAJ. Physiol Rep. 2019 Dec;7(23):e14299. doi: 10.14814/phy2.14299.

Depletion of the mRNA translation initiation inhibitor, programmed cell death protein 4 (PDCD4), impairs L6 myotube formation.

Maeda N, Abdullahi A, Beatty B, Dhanani Z, Adegoke OAJ. Physiol Rep. 2017 Sep;5(17). pii: e13395. doi: 10.14814/phy2.13395.

Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner. Moghei M, Tavajohi-Fini P, Beatty B, Adegoke OA. Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C518-27.

Exercise in ZDF rats does not attenuate weight gain, but prevents hyperglycemia concurrent with modulation of amino acid metabolism and AKT/mTOR activation in skeletal muscle.. Adegoke OA, Bates HE, Kiraly MA, Vranic M, Riddell MC, Marliss EB. Eur J Nutr. 2015 Aug;54(5):751-9.

Amino acid-induced impairment of insulin sensitivity in healthy and obese rats is reversible. Jeganathan S, Abdullahi A, Zargar S, Maeda N, Riddell MC, Adegoke OA. Physiol Rep. 2014 Jul 4;2(7).

Dhanshri Kakade, Nushaba Islam, Naomi Maeda and Olasunkanmi A. J. Adegoke. Differential effects of PDCD4 depletion on protein synthesis in myoblast and myotubes. BMC Cell Biol. 2014 Jan 9;15:2.

Adegoke OAJ, Abdullahi A, and Tavajohi-Fini P. mTORC1 and the regulation of skeletal muscle anabolism and mass. Applied Physiology Nutrition and Metabolism. 2012 Jun;37(3):395-406. doi: 10.1139/h2012-009. Epub 2012 Apr 17. Review.

 

 Serino AS, Adegoke OAJ, Zargar S, Gordon CS, Szigiato AA, Hawke TJ, Riddell MC. Voluntary physical activity and leucine correct impairments in muscle protein synthesis in partially pancreatectomised rats. Diabetologia. 2011 Dec;54(12):3111-20.

 

Zargar S, Moreira TS, Samimi-Seisan H, Jeganathan S, Kakade D, Islam N, Campbell J, Adegoke OAJ. Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeedin in rats.  Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E986-92. Epub 2011 Mar 15.

 

Gordon CS, Serino AS, Krause MP, Campbell JE, Cafarelli E, Adegoke OAJ, Hawke TJ, Riddell MC. Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy? PLoS One. 2010 Nov 17;5(11):e14032.

 

Harding V Scott, Adegoke OAJ, Fraser KG, Marliss EB, Chevalier S, Kimball SR, Jefferson LS, Wykes LJ.  Maintaining adequate nutrition, not probiotic administration, prevents growth stunting and maintains skeletal muscle protein synthesis rates in a piglet model of colitis. Pediatr Res 67 (3): 268-73, 2010.

 Adegoke OAJ, Chevalier S, Morais JA, Gougeon R, Kimball SR, Jefferson LS, Wing SS, and Marliss EB. The fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men. Am J Physiol Endocrinol Metab 296(1):E105-13, 2009.

Yu L, Adegoke OAJ, Nepveu A, Nakayama KI, Bedard N, Cheng D, Peng J, and SS Wing. USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol 29 (2), p. 547–558, 2009.

Schricker T, Meterissian S, Latterman R, Marliss EB, Adegoke OAJ, Mazza L, Eberhart L, Carli F, Nitschman E, and Wykes LJ. Avoidance of preoperative fasting by intravenous hypocaloric nutrition reduces whole body protein catabolism and stimulates albumin synthesis after surgery. Ann Surg 248(6):1051-9, 2008.

 

EB Marliss, S Chevalier, R Gougeon, JA Morais, M Lamarche, Adegoke OAJ and G Wu. Elevations of plasma methylarginines in obesity and aging are related to insulin sensitivity and rates of protein turnover. Diabetologia 2006, 49(2): 351-359.



  L Combaret, Adegoke OAJ, N Bedard, VE Baracos and SS Wing. USP19 is a ubiquitin specific protease regulated in rat skeletal muscle during catabolic states. Am J Physiol 2005, 288(4): E693-700.

 

 Adegoke OAJ, MI McBurney, SE Samuels and VE Baracos. Modulation of intestinal protein synthesis and protease mRNA by luminal and systemic nutrients. Am J Physiol 2003, 284: G1017-1026.



  Adegoke OAJ, N Bedard, HP Roest and SS Wing. Ubiquitin-conjugating enzyme E214k/HR6B is dispensable for increased protein catabolism in muscle of fasted mice. Am J Physiol 2002, 283: E482-489.

R Oughtred, N Bedard, Adegoke OAJ, CR Morales, J Trasler, V Rajapurohitam and SS Wing. Characterization of rat 100, a 300 kDa ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene. Endocrinology 2002, 143 (10): 3740-3747.

 

VE Baracos, SE Samuels and Adegoke OAJ. Anabolic and catabolic mediators of intestinal protein turnover: a new experimental approach. Curr Opin Clin Nutr Metab Care 2000, May; 3(3): 183-189.

Affiliations

Canadian Nutrition Society

Canadian Soceity for Exercise Physiology

American Society for Nutrition

American Physiological Society

Service/Community Activities

Black Creek Community Health Centre
Vice Chair of the Board of Directors

Supervision

Currently available to supervise graduate students: Yes

Currently taking on work-study students, Graduate Assistants or Volunteers: No

Available to supervise undergraduate thesis projects: Yes

Current Research

Research in my lab focuses on molecular mechanisms regulating skeletal muscle growth and metabolism. We examine how these are modified by diet and physical activity in health and diseases like obesity and diabetes. Skeletal muscle constitutes about 40% of body mass. Because healthy muscle consists mainly of proteins, an understanding of mechanisms regulating protein metabolism is fundamental to health and vital to prevention/ management of several chronic diseases. Indeed altered protein metabolism underlies or worsens conditions such as obesity, diabetes, cancers and diverse myopathies. Ongoing projects in the lab include:

1) Identification and regulation of factors that regulate protein synthesis and mRNA translation in skeletal muscle. We are especially interested in how such factors are regulated by nutrition and physical activity, and in rodent models of obesity and type 2 diabetes. 

2) Molecular mechanisms of insulin resistance of skeletal muscle in obesity. We examine the roles of amino acids in mediating alterations in insulin signalling and the consequence of such on muscle metabolism. We study the roles of targeted proteolysis by ubiquitin-proteolytic system in regulating proteins that are vital to insulin signalling.

3) Regulation of muscle mRNA translation initiation factors during myogenesis, a process that is vital for muscle development and repair. We are studying the functions of mRNA translation initiation factors during myogenesis, and the influence of nutrition on those functions.

Research Projects

See previous section
Role: Principal Investigator
Funded by: Natural Sciences and Engineering Research Council