Anthony Scimè

Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science

Degrees

PhD -
McMaster
Hamilton

Selected Publications

Bhattacharya D, Shah V, Oresajo, OJ and Scimè, A. (2021). p107 mediated mitochondrial function controls muscle stem cell proliferative fates. Nature Communications. 12:5977.

Bhattacharya D and Scimè A. (2020). Mitochondrial function in muscle stem cell fates. Front Endocrinol (Lausanne). 2019 Jun 16;8:480 DOI: 10.3389/fcell.2020.00480

Cantini G, Di Franco A, Mannelli M, Scimè A, Maggi M and Luconi M. (2020). The role of metabolic changes in shaping the fate of cancer-associated adipose stem cells. Front Endocrinol (Lausanne). Apr 16;10:773 DOI: 10.3389/fcell.2020.00332

Bhattacharya D and Scimè A. (2019). Metabolic regulation of epithelial to mesenchymal transition: Implications for endocrine cancer. Front Endocrinol (Lausanne). 2019 Nov 26;10:773 DOI:10.3389/fendo.2019.00773

Porras DP, Abbaszadeh M, Bhattacharya D, D’Souza NC, Edjiu NR, Perry CGR and Scimè A. (2017). p107 determines a metabolic checkpoint required for adipocyte lineage fates. Stem Cells. 2017 May;35(5):1378-1391.

Bhattacharya D, Ydfors M, Hughes MC, Norrbom J, Perry CGR and Scimè A. (2017). Decreased transcriptional corepressor p107 is associated with exercise-induced mitochondrial biogenesis in human skeletal muscle. Physiol Rep. 2017 Mar;5(5). pii: e13155.

 

Awards

Award of Excellence - 2006
University of Ottawa

Supervision

Currently available to supervise graduate students: Yes

Currently taking on work-study students, Graduate Assistants or Volunteers: Yes

Available to supervise undergraduate thesis projects: Yes

Current Research

The Scimè lab is focused on understanding the molecular, cellular and physiological aspects for how metabolism is involved in stem cell fate choices particularly in muscle and adipose tissue. Stem and progenitor cell fates have a profound impact on health and disease progression. Adipose and muscle tissue are inextricably linked to many metabolic pathways, and their dysregulation are associated with many complications and disease. No more so than in the ever-increasing prevalence of disorders such as type II diabetes, obesity, cancer and sarcopenia. A key component of muscle and adipose tissue function is provided by their stem cells that are necessary for tissue development, maintenance and disposition. At the cellular level stem cell fate choices of quiescence, activation, differentiation and self-renewal are bio energetically balanced through proper regulation of metabolic pathways. Ongoing studies are 1) to determine the role of cellular metabolism on stem cell fate choices in various tissue types 2) to assess the role of whole body stressors, such as exercise and diet on stem cell behavior and 3) to find the impact of altered metabolism on cancer stem function and micro environment.